Reticulocytes

Reticulocytes are immature red blood cells, typically making up about 1% of the red cells in the human body. They develop and mature in the bone marrow and then circulate for about a day in the bloodstream before developing into mature red blood cells. Like mature red blood cells, they do not have a cell nucleus. They are called reticulocytes because of a reticular (mesh-like) network of ribosomal RNA that becomes visible under a microscope with certain stains such as New Methylene Blue.

Production

Reticulocytes are produced in the bone marrow and sent into the bloodstream. About two days before they mature into red blood cells, they eject their nucleus. The absence of a nucleus is a characteristic shared among all types of red blood cells.

Function

The primary function of reticulocytes is to provide new red blood cells. The body uses feedback mechanisms to regulate the production of these cells. If the body needs more oxygen, it produces more reticulocytes. If there are enough red blood cells, the body decreases reticulocyte production.

Clinical significance

Reticulocyte counts can provide important information about a person's health. High levels of reticulocytes can indicate conditions such as anemia, hemorrhage, or hemolysis. Low levels can indicate conditions such as iron deficiency, vitamin B12 deficiency, or folic acid deficiency.

See also

• Complete blood count
• Hematocrit
• Hemoglobin
• Red blood cell

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