Retinol binding protein
Retinol binding protein (RBP) is a protein that in humans is encoded by the RBP1 gene. RBP is the carrier protein responsible for the transport of retinol (vitamin A alcohol) from the liver storage sites to the peripheral tissues. In plasma, RBP is bound to transthyretin, which prevents its loss by filtration through the kidney glomeruli.
Function[edit | edit source]
Retinol binding protein is the primary carrier of retinol in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, which prevents the loss of the complex into the urine and ensures its delivery to the tissues that need it.
Structure[edit | edit source]
The RBP protein belongs to the lipocalin family and is a single polypeptide chain with one direct repeat. The repeat sequence is highly conserved in all species as well as in other proteins of the lipocalin family.
Clinical significance[edit | edit source]
Mutations in the RBP1 gene are associated with microphthalmia, a severe eye disorder, and other ocular abnormalities. RBP may also play a role in the development of obesity and insulin resistance.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
Retinol binding protein Resources | ||
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