Runcaciguat
Runcaciguat is a pharmaceutical drug that acts as a soluble guanylate cyclase (sGC) stimulator. It is primarily being investigated for its potential therapeutic effects in treating cardiovascular diseases and other conditions related to impaired nitric oxide (NO) signaling.
Mechanism of Action[edit | edit source]
Runcaciguat works by stimulating the enzyme soluble guanylate cyclase (sGC), which is a key component in the nitric oxide (NO) signaling pathway. This enzyme catalyzes the conversion of guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), a secondary messenger that plays a crucial role in vasodilation and other physiological processes. By enhancing the activity of sGC, runcaciguat increases the levels of cGMP, leading to improved blood flow and reduced blood pressure.
Therapeutic Applications[edit | edit source]
Runcaciguat is being studied for its potential use in various medical conditions, including:
Clinical Trials[edit | edit source]
Several clinical trials are underway to evaluate the safety and efficacy of runcaciguat in different patient populations. These trials aim to determine the optimal dosing, potential side effects, and overall therapeutic benefits of the drug.
Side Effects[edit | edit source]
As with any medication, runcaciguat may cause side effects. Common side effects observed in clinical trials include:
Related Compounds[edit | edit source]
Runcaciguat is part of a class of drugs known as sGC stimulators. Other drugs in this class include:
See Also[edit | edit source]
- Soluble guanylate cyclase
- Nitric oxide
- Cyclic guanosine monophosphate
- Pulmonary hypertension
- Heart failure
References[edit | edit source]
External Links[edit | edit source]
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Categories[edit | edit source]
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