S-268019
S-268019 is a pharmacological agent that is classified as a serotonin 5-HT3 receptor antagonist. It is primarily used in the treatment of chemotherapy-induced nausea and vomiting (CINV).
Pharmacology[edit | edit source]
S-268019 works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. It is a highly selective 5-HT3 receptor antagonist with strong binding affinity for the 5-HT3 receptor.
Clinical Use[edit | edit source]
The primary use of S-268019 is in the prevention and treatment of nausea and vomiting associated with chemotherapy. It is particularly effective in managing CINV that is resistant to other antiemetic therapies.
Side Effects[edit | edit source]
Common side effects of S-268019 include constipation, headache, and fatigue. In rare cases, it may cause serious side effects such as serotonin syndrome, a potentially life-threatening condition that requires immediate medical attention.
Dosage[edit | edit source]
The dosage of S-268019 varies depending on the severity of the patient's symptoms and their overall health status. It is typically administered as an intravenous infusion prior to chemotherapy treatment.
See Also[edit | edit source]
References[edit | edit source]
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