S-777,469

S-777,469 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.88 nM at CB2 and 7360 nM at CB1, giving it around 8000x selectivity for CB2. It has antiinflammatory effects in animal studies, and is used for research into new antiinflammatory drugs.

Pharmacology

S-777,469 is a potent and selective agonist for the cannabinoid receptor CB2. The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily. The CB2 receptor is primarily found in the immune system, and is less widespread in the central nervous system than the CB1 receptor. The CB2 receptor is associated with immune system regulation and inflammation response, which is why S-777,469 has potential as an antiinflammatory drug.

Chemistry

S-777,469 is a synthetic compound. Its chemical structure is distinct from the classical cannabinoids, instead being a derivative of the indazole class of compounds. It is a full agonist for the CB2 receptor, meaning it can fully activate the receptor in the absence of other agonists.

Research and Potential Uses

Research into S-777,469 is primarily focused on its potential as an antiinflammatory drug. In animal studies, it has been shown to reduce inflammation and associated pain. This makes it a potential candidate for the development of new antiinflammatory drugs, particularly for conditions where inflammation is a major factor, such as rheumatoid arthritis and inflammatory bowel disease.

See Also

• Cannabinoid receptor
• Agonist
• Antiinflammatory
• G protein-coupled receptor
• Immune system
• Central nervous system
• Indazole
• Rheumatoid arthritis
• Inflammatory bowel disease

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