S-Adenosylmethionine

Overview of S-Adenosylmethionine (SAMe)

S-Adenosylmethionine (SAMe, SAM) is a compound that is involved in several important biochemical processes in the body. It is a methyl donor in transmethylation reactions, which are critical for the synthesis of neurotransmitters, nucleic acids, and phospholipids.

Biological Role

SAMe is synthesized from adenosine triphosphate (ATP) and methionine by the enzyme methionine adenosyltransferase. It acts as a methyl donor in the synthesis of epinephrine, serotonin, and dopamine, which are important neurotransmitters in the central nervous system.

Medical Uses

SAMe is used as a dietary supplement for the treatment of depression, osteoarthritis, and liver disease. It is believed to enhance the production of neurotransmitters and improve mood in individuals with depression.

Depression

Studies have shown that SAMe may be effective in alleviating symptoms of depression, particularly in individuals who do not respond to conventional antidepressants.

Osteoarthritis

SAMe has been used to reduce pain and improve joint function in individuals with osteoarthritis. It is thought to stimulate the production of proteoglycans, which are essential components of cartilage.

Liver Disease

SAMe is also used in the management of liver disease, as it may help to restore glutathione levels and protect against oxidative stress.

Side Effects

Common side effects of SAMe include gastrointestinal symptoms such as nausea, diarrhea, and bloating. It may also cause insomnia and headache in some individuals.

Interactions

SAMe may interact with other medications, including antidepressants, levodopa, and serotonin reuptake inhibitors. It is important to consult a healthcare provider before using SAMe, especially if taking other medications.

See Also

• Methylation
• Neurotransmitter
• Liver function

External Links

• S-Adenosylmethionine on WikiMD