S-Adenosylmethionine

Overview of S-Adenosylmethionine (SAMe)

S-Adenosylmethionine
INN
Drug class
Routes of administration	Oral, Intravenous
Pregnancy category
Bioavailability
Metabolism	Liver
Elimination half-life
Excretion
Legal status
CAS Number	29908-03-0
PubChem	34756
DrugBank	DB00118
ChemSpider	31998
KEGG	D00052

S-Adenosylmethionine (SAMe, SAM) is a compound that is involved in several important biochemical processes in the body. It is a methyl donor in transmethylation reactions, which are critical for the synthesis of neurotransmitters, nucleic acids, and phospholipids.

Biological Role

SAMe is synthesized from adenosine triphosphate (ATP) and methionine by the enzyme methionine adenosyltransferase. It acts as a methyl donor in the synthesis of epinephrine, serotonin, and dopamine, which are important neurotransmitters in the central nervous system.

Medical Uses

SAMe is used as a dietary supplement for the treatment of depression, osteoarthritis, and liver disease. It is believed to enhance the production of neurotransmitters and improve mood in individuals with depression.

Depression

Studies have shown that SAMe may be effective in alleviating symptoms of depression, particularly in individuals who do not respond to conventional antidepressants.

Osteoarthritis

SAMe has been used to reduce pain and improve joint function in individuals with osteoarthritis. It is thought to stimulate the production of proteoglycans, which are essential components of cartilage.

Liver Disease

SAMe is also used in the management of liver disease, as it may help to restore glutathione levels and protect against oxidative stress.

Side Effects

Common side effects of SAMe include gastrointestinal symptoms such as nausea, diarrhea, and bloating. It may also cause insomnia and headache in some individuals.

Interactions

SAMe may interact with other medications, including antidepressants, levodopa, and serotonin reuptake inhibitors. It is important to consult a healthcare provider before using SAMe, especially if taking other medications.

See Also

• Methylation
• Neurotransmitter
• Liver function

External Links

• S-Adenosylmethionine on WikiMD