S100A6

S100A6

S100A6 is a protein that belongs to the S100 family of calcium-binding proteins. It is also known as calcyclin or growth factor-inducible protein 2A9 (GIF2A9). S100A6 is encoded by the S100A6 gene, which is located on chromosome 1q21.

Structure

S100A6 consists of two EF-hand calcium-binding motifs, which are characteristic of the S100 protein family. These motifs allow S100A6 to bind calcium ions, which in turn regulates its function. The protein has a molecular weight of approximately 10.5 kDa.

Function

S100A6 is involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. It has been shown to interact with a wide range of target proteins, including p53, cyclin-dependent kinase inhibitors, and various signaling molecules. Through these interactions, S100A6 plays a role in regulating cell cycle progression, cell growth, and cell survival.

Clinical Significance

Abnormal expression of S100A6 has been observed in several types of cancer, including breast, lung, and pancreatic cancer. Overexpression of S100A6 has been associated with tumor progression and poor prognosis in some cases. Therefore, S100A6 has been proposed as a potential biomarker for cancer diagnosis and prognosis.

See Also

• S100 protein family
• Calcium-binding protein
• Cell proliferation
• Apoptosis

External Links

• S100A6 gene at NCBI
• S100A6 protein at UniProt