S1PR5

S1PR5 or Sphingosine-1-phosphate receptor 5 is a protein that in humans is encoded by the S1PR5 gene. It is a member of the sphingosine-1-phosphate receptor family, which is a group of G protein-coupled receptors that are involved in a variety of cellular processes.

Function

S1PR5 is a receptor for the bioactive lipid sphingosine-1-phosphate (S1P). S1P is a circulating lipid mediator that regulates a multitude of physiological processes, including immune response, cardiovascular development, and lymphocyte trafficking. S1PR5 is expressed in various tissues, with high levels in the white blood cells and spleen.

Clinical significance

Alterations in the function of S1PR5 have been implicated in various diseases. For example, it has been suggested that S1PR5 may play a role in the pathogenesis of multiple sclerosis by regulating the migration of lymphocytes into the central nervous system. In addition, S1PR5 has been associated with the progression of cancer, as it can promote the migration and invasion of cancer cells.

Research

Research into the role of S1PR5 in health and disease is ongoing. Current areas of interest include its potential as a therapeutic target in conditions such as autoimmune diseases, cancer, and neurodegenerative diseases.

File:S1PR5.png

S1PR5 protein structure. Image from Wikimedia Commons.

See also

• Sphingosine-1-phosphate receptor
• G protein-coupled receptor
• Multiple sclerosis
• Cancer