SERF2

SERF2 (Small EDRK-Rich Factor 2) is a protein that in humans is encoded by the SERF2 gene. This gene is located on chromosome 15 and is involved in various cellular processes.

Function

The SERF2 protein is implicated in the regulation of protein folding and protein aggregation. It plays a role in the cellular response to stress and is believed to be involved in the maintenance of protein homeostasis. The exact mechanisms by which SERF2 functions are still under investigation, but it is known to interact with other proteins involved in the unfolded protein response.

Structure

The SERF2 protein is characterized by its small size and the presence of an EDRK-rich domain, which is thought to be important for its function. The structure of SERF2 allows it to interact with a variety of other proteins, facilitating its role in protein folding and aggregation.

Expression

SERF2 is ubiquitously expressed in various tissues, with higher expression levels observed in the brain, heart, and muscle tissues. Its expression is regulated by various factors, including stress response pathways.

Clinical Significance

Mutations or dysregulation of the SERF2 gene have been associated with several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Research is ongoing to determine the potential of SERF2 as a therapeutic target for these conditions.

Research

Current research on SERF2 focuses on understanding its role in protein homeostasis and its potential involvement in disease processes. Studies are also exploring the interactions between SERF2 and other proteins involved in the unfolded protein response and protein aggregation.

See Also

• Protein folding
• Unfolded protein response
• Neurodegenerative diseases
• Protein homeostasis