SHFM1

From WikiMD's Wellness Encyclopedia


26S proteasome complex subunit DSS1 is a protein that in humans is encoded by the SHFM1 gene.[1][2][3]

Function[edit | edit source]

The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle.[3]

Interactions[edit | edit source]

SHFM1 has been shown to interact with BRCA2.[4][5]

References[edit | edit source]

  1. 3.0 3.1 "Entrez Gene: SHFM1 split hand/foot malformation (ectrodactyly) type 1".

Further reading[edit | edit source]


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Contributors: Prab R. Tumpati, MD