SLC16A1

SLC16A1 (also known as Monocarboxylate transporter 1 or MCT1) is a protein that in humans is encoded by the SLC16A1 gene. It is a member of the solute carrier family 16, which is also known as the monocarboxylate transporter family. This family consists of several proteins that facilitate the transport of various metabolites across the plasma membrane.

Function

The SLC16A1 protein is a proton-linked monocarboxylate transporter that catalyzes the rapid transport of many monocarboxylates such as lactate, pyruvate, and ketone bodies across the plasma membrane. It is widely expressed in many tissues with notable exceptions of liver and adipose tissue.

Clinical significance

Mutations in the SLC16A1 gene are associated with symptomatic deficiency in lactate transport (SDLT). SDLT is an autosomal recessive disease characterized by the interruption of lactate transport across the cell membrane.

See also

• Solute carrier family
• Monocarboxylate transporter
• Lactate transporter

External links

• SLC16A1 at the US National Library of Medicine Medical Subject Headings (MeSH)

SLC16A1 Resources
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