SLC39A11

Ideogram human chromosome 17

SLC39A11

SLC39A11 is a gene that encodes a protein involved in the transport of zinc ions across cell membranes. This gene is located on chromosome 17 in humans. The protein encoded by SLC39A11 is a member of the SLC39 family of metal ion transporters.

Function

The protein product of SLC39A11 plays a crucial role in maintaining zinc homeostasis within cells. Zinc is an essential micronutrient that is involved in various cellular processes, including DNA synthesis, immune function, and wound healing. The transport of zinc ions by SLC39A11 is necessary for these processes to occur efficiently.

Clinical Significance

Mutations in the SLC39A11 gene have been associated with various health conditions, including zinc deficiency and neurological disorders. Dysregulation of zinc homeostasis due to mutations in SLC39A11 can lead to impaired growth and development, as well as neurological symptoms such as seizures and cognitive deficits.

Regulation

The expression of SLC39A11 is tightly regulated at the transcriptional and post-transcriptional levels. Various factors, including dietary zinc intake and cellular stress, can influence the expression of SLC39A11. Understanding the regulatory mechanisms of SLC39A11 may provide insights into potential therapeutic strategies for conditions associated with zinc dysregulation.

Interactions

SLC39A11 interacts with other proteins involved in zinc metabolism and cellular signaling pathways. These interactions play a crucial role in coordinating the transport of zinc ions across different cellular compartments. Disruption of these interactions can impact cellular functions that rely on proper zinc homeostasis.