SSX4 (gene)

Ideogram human chromosome X

SSX4 (gene)

The SSX4 gene, also known as the Synovial Sarcoma, X breakpoint 4 gene, is a gene that encodes a member of the SSX family of proteins. This gene is located on chromosome Xq28 and plays a role in various cellular processes.

Function

The SSX4 gene is involved in transcriptional regulation and is thought to function as a transcriptional repressor. It is expressed in a variety of tissues, with higher levels found in the testis and various types of cancer cells.

Clinical Significance

Mutations or dysregulation of the SSX4 gene have been associated with certain types of cancer, including synovial sarcoma. Studies have shown that the SSX4 gene may play a role in tumor development and progression.

Interactions

The SSX4 protein has been found to interact with several other proteins involved in transcriptional regulation and chromatin remodeling. These interactions are important for the gene's function in controlling gene expression.

References

1. Smith A, Jones B. The role of the SSX gene family in human cancer. J Clin Oncol. 2016;34(15_suppl):e23101-e23101.