ST8SIA6
ST8SIA6[edit | edit source]
ST8SIA6 is a gene that encodes a member of the sialyltransferase family of enzymes. These enzymes are responsible for the transfer of sialic acid to glycoproteins and glycolipids, which are important for cell-cell interaction, signaling, and stability of glycoproteins.
Function[edit | edit source]
The ST8SIA6 gene encodes an enzyme that is involved in the biosynthesis of polysialic acid, a carbohydrate polymer that modifies the neural cell adhesion molecule (NCAM). Polysialylation of NCAM is crucial for neural development and plasticity.
Clinical Significance[edit | edit source]
Mutations or dysregulation of the ST8SIA6 gene may be associated with neurological disorders due to its role in neural development. Research is ongoing to determine the specific implications of ST8SIA6 in various neurological disorders.
Related Genes[edit | edit source]
ST8SIA6 is part of a larger family of sialyltransferases, which includes other genes such as ST8SIA1, ST8SIA2, and ST8SIA4. These genes have similar functions but may differ in their specific substrates and tissue distribution.
Research[edit | edit source]
Current research is focused on understanding the role of ST8SIA6 in the central nervous system and its potential involvement in neurodevelopmental disorders. Studies are also exploring the possibility of targeting ST8SIA6 for therapeutic interventions in diseases where polysialylation is disrupted.
External Links[edit | edit source]
References[edit | edit source]
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