STAMPEDE (clinical trial)

From WikiMD.com Medical Encyclopedia

A large clinical trial investigating treatments for prostate cancer


STAMPEDE (clinical trial)[edit | edit source]

Error creating thumbnail:
Prostate cancer cells

The STAMPEDE trial (Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy) is a large, multi-arm, multi-stage clinical trial designed to evaluate the effectiveness of various treatments for prostate cancer. It is one of the largest randomized controlled trials in prostate cancer, aiming to improve outcomes for men with high-risk, locally advanced, or metastatic prostate cancer.

Background[edit | edit source]

Prostate cancer is one of the most common cancers affecting men worldwide. Traditional treatments have included surgery, radiotherapy, and hormone therapy. However, the optimal combination and sequence of these treatments, especially in advanced stages, have been subjects of ongoing research. The STAMPEDE trial was initiated to address these questions by testing new treatment strategies and combinations.

Design[edit | edit source]

The STAMPEDE trial uses a multi-arm, multi-stage (MAMS) design, which allows for the simultaneous testing of several treatment strategies against a common control group. This innovative design enables the trial to adapt over time, adding new treatment arms as promising therapies emerge and dropping ineffective ones. This approach increases the efficiency of the trial and accelerates the evaluation of new treatments.

Treatment Arms[edit | edit source]

The trial has included various treatment arms over time, testing combinations of standard hormone therapy with additional treatments such as:

Each arm is compared to the standard of care, which typically involves androgen deprivation therapy (ADT).

Outcomes[edit | edit source]

The primary outcome measure for the STAMPEDE trial is overall survival, with secondary outcomes including progression-free survival, quality of life, and cost-effectiveness. The trial has provided significant insights into the management of advanced prostate cancer, influencing clinical guidelines and practice.

Impact[edit | edit source]

Results from the STAMPEDE trial have led to changes in the standard treatment for advanced prostate cancer. For example, the addition of docetaxel or abiraterone to standard hormone therapy has been shown to improve survival in men with newly diagnosed metastatic prostate cancer. These findings have been incorporated into treatment guidelines worldwide.

Future Directions[edit | edit source]

The STAMPEDE trial continues to evolve, with new treatment arms being added to explore emerging therapies and combinations. The trial's adaptive design allows it to remain at the forefront of prostate cancer research, providing ongoing contributions to the understanding and treatment of the disease.

Related pages[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD