STK10

STK10

STK10, also known as Serine/Threonine Kinase 10, is a protein encoded by the STK10 gene in humans. This kinase is a member of the Ste20-like kinase family and plays a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and signal transduction pathways.

Structure

STK10 is a serine/threonine kinase, which means it phosphorylates target proteins on serine or threonine residues. The protein structure of STK10 includes a kinase domain that is responsible for its enzymatic activity. This domain is highly conserved among kinases and is critical for ATP binding and substrate recognition.

Function

STK10 is involved in several cellular functions:

• Cell Cycle Regulation: STK10 is implicated in the regulation of the cell cycle, particularly in the transition from the G1 phase to the S phase. It ensures that cells only proceed to DNA replication when they are ready.

• Apoptosis: STK10 can influence apoptotic pathways, acting as a pro-apoptotic factor under certain conditions. This function is crucial for maintaining cellular homeostasis and preventing uncontrolled cell proliferation.

• Signal Transduction: As a kinase, STK10 is involved in various signaling pathways. It can phosphorylate downstream targets, thereby modulating their activity and influencing cellular responses to external stimuli.

Clinical Significance

Alterations in the expression or function of STK10 have been associated with several diseases, including cancer. Overexpression or mutations in STK10 can lead to aberrant cell signaling and contribute to tumorigenesis. Therefore, STK10 is considered a potential target for therapeutic intervention in cancer treatment.

Research

Ongoing research is focused on understanding the precise mechanisms by which STK10 regulates cellular processes and its role in disease. Studies are also exploring the potential of STK10 inhibitors as therapeutic agents in oncology.

Also see

• Protein kinase
• Signal transduction
• Apoptosis
• Cell cycle

Resources

Latest articles - STK10

• Most recent articles
• Ongoing trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on STK10 for any updates.

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