SUPT4H1

Ideogram house mouse chromosome 11

SUPT4H1

SUPT4H1 is a gene that encodes a protein known as Suppressor of Ty 4 homolog 1. This gene is located on chromosome 11 in humans. The protein encoded by SUPT4H1 is involved in various cellular processes, including transcriptional regulation and RNA processing.

Function

The SUPT4H1 protein is a subunit of the transcription elongation factor SII, which is involved in the regulation of RNA polymerase II-mediated transcription. It plays a crucial role in the elongation phase of transcription by facilitating the movement of RNA polymerase along the DNA template.

Clinical Significance

Mutations in the SUPT4H1 gene have been associated with certain diseases, although the exact mechanisms are still being studied. Research suggests that dysregulation of SUPT4H1 expression may contribute to the development of certain cancers and other disorders.

Interactions

The SUPT4H1 protein has been found to interact with various other proteins involved in transcriptional regulation and RNA processing. These interactions are essential for the proper functioning of the transcription elongation complex and the regulation of gene expression.