Saccharomyces Genome Database

Saccharomyces Genome Database (SGD) is a scientific database dedicated to the biology and genetics of the yeast Saccharomyces cerevisiae. As a model organism, S. cerevisiae has been extensively studied, making the SGD an essential resource for researchers in genetics, molecular biology, and biotechnology. The database provides a comprehensive and curated collection of genetic and molecular biology data for Saccharomyces cerevisiae, including gene descriptions, chromosomal mapping, protein function, and interaction networks.

Overview

The SGD project was initiated in the early 1990s as part of a broader effort to sequence the Saccharomyces cerevisiae genome. Since then, it has evolved into a critical resource for the yeast research community, offering tools and information to study the organism's biology at a molecular level. The database is maintained by a team of scientists and bioinformaticians who curate information from scientific literature and direct submissions from researchers.

Features

SGD provides several key features to its users:

• Gene Summaries: Detailed descriptions of each gene in the S. cerevisiae genome, including its function, structure, and regulatory mechanisms.
• Genetic and Physical Maps: Tools to visualize the location of genes on chromosomes, facilitating studies on gene linkage and chromosomal organization.
• Protein Information: Data on protein sequences, structures, and functional domains, enabling research into protein function and interaction networks.
• Genome Browser: An interactive tool that allows users to explore the S. cerevisiae genome, viewing gene annotations and sequence alignments.
• Literature Database: A collection of scientific publications related to S. cerevisiae research, providing a comprehensive reference for users.

Applications

The SGD is utilized by researchers for a variety of applications, including:

• Identifying gene functions and interactions to understand cellular processes.
• Studying the genetic basis of diseases using S. cerevisiae as a model system.
• Developing biotechnological applications, such as yeast-based production of pharmaceuticals and biofuels.
• Investigating evolutionary biology by comparing the S. cerevisiae genome with those of other species.

Access

The Saccharomyces Genome Database is freely accessible online, providing an invaluable resource for the global scientific community. Users can search for specific genes or proteins, browse the genome, or download data for their own analyses.

Future Directions

The SGD continues to evolve, with ongoing efforts to update and expand its content. Future developments may include more sophisticated tools for data analysis and visualization, as well as enhanced integration with other databases and computational resources. The goal is to maintain the SGD as a cutting-edge resource that supports and advances research in yeast biology and genetics.