Salicylamide

Salicylamide is an nonsteroidal anti-inflammatory drug (NSAID) that is less potent than aspirin. It is used as an analgesic and antipyretic. Salicylamide is also used in combination with both aspirin and caffeine in the over-the-counter medications PainAid, Excedrin and Vanquish.

Chemistry

Salicylamide is the amide derivative of salicylic acid. It is a white, crystalline, odorless powder with a slightly bitter taste. It is sparingly soluble in cold water, ether, and chloroform, and soluble in alcohol and hot water.

Pharmacology

Salicylamide's mechanism of action is similar to that of aspirin. It inhibits prostaglandin synthesis and peripherally blocks pain impulse generation. It also produces antipyresis by acting on the hypothalamus to produce peripheral vasodilation and sweating.

Side Effects

Common side effects of salicylamide include nausea, vomiting, and gastrointestinal discomfort. More serious side effects can include tinnitus, dizziness, and hyperventilation.

Interactions

Salicylamide can interact with other drugs such as warfarin, increasing the risk of bleeding. It can also interact with other NSAIDs, increasing the risk of gastrointestinal side effects.

See Also

• Nonsteroidal anti-inflammatory drug
• Aspirin
• Salicylic acid

Salicylamide Resources
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