Saquinavir mesylate

Saquinavir mesylate is an antiretroviral drug used in the treatment of HIV infections. It belongs to the class of drugs known as protease inhibitors, which work by preventing the virus from replicating within the body. Saquinavir mesylate is often used in combination with other antiretroviral drugs as part of HAART.

History

Saquinavir mesylate was the first protease inhibitor approved by the FDA in the United States in 1995. It was developed by the pharmaceutical company Roche.

Mechanism of Action

Saquinavir mesylate works by inhibiting the action of the HIV protease, an enzyme that the virus needs to replicate. By blocking this enzyme, the drug prevents the virus from multiplying, thereby reducing the amount of virus in the body.

Usage

Saquinavir mesylate is used in combination with other antiretroviral drugs as part of a HAART regimen. It is not used alone due to the risk of the virus developing resistance to the drug.

Side Effects

Common side effects of saquinavir mesylate include nausea, diarrhea, and abdominal pain. More serious side effects can include liver problems and changes in heart rhythm.

Drug Interactions

Saquinavir mesylate can interact with a number of other medications, including other antiretroviral drugs, certain antibiotics and antifungal medications, and drugs used to treat heart conditions. It is important for patients to inform their healthcare provider of all medications they are taking.

See Also

• Antiretroviral drug
• Protease inhibitors
• HAART
• HIV