Sarmazenil
Sarmazenil is a benzodiazepine derivative drug that is a partial inverse agonist of the GABA_A receptor. It was developed by Hoffmann-La Roche in the 1980s as a potential treatment for benzodiazepine dependence and withdrawal syndrome.
Pharmacology[edit | edit source]
Sarmazenil acts as a partial inverse agonist at the GABA_A receptor, meaning it produces effects opposite to those of benzodiazepine drugs, which are GABA_A receptor agonists. This makes it useful in the treatment of benzodiazepine dependence and withdrawal syndrome, as it can help to reverse the effects of benzodiazepine drugs and reduce withdrawal symptoms.
Clinical Use[edit | edit source]
Sarmazenil has been studied in clinical trials for the treatment of benzodiazepine dependence and withdrawal syndrome. However, it has not been widely adopted in clinical practice, possibly due to its partial inverse agonist activity, which can potentially cause withdrawal symptoms in patients who are dependent on benzodiazepines.
Side Effects[edit | edit source]
As a partial inverse agonist of the GABA_A receptor, sarmazenil can potentially cause side effects such as anxiety, restlessness, and insomnia. These side effects are similar to those of benzodiazepine withdrawal syndrome, which can make it difficult to distinguish between the effects of the drug and the symptoms of withdrawal.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
