Senolytic
Senolytic is a type of drug that selectively induces apoptosis of senescent cells. Senescent cells are cells that have stopped dividing and have accumulated in the body with age. They contribute to aging and age-related diseases. Senolytics are a potential therapy for these diseases.
Mechanism of Action[edit | edit source]
Senolytics work by selectively inducing apoptosis, or programmed cell death, in senescent cells. They do this by inhibiting the survival pathways that these cells rely on. The two main pathways targeted by senolytics are the BCL-2 pathway and the PI3K/AKT pathway.
Types of Senolytics[edit | edit source]
There are several types of senolytics, including:
- Quercetin: A plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, and grains.
- Dasatinib: A medication used to treat certain cases of chronic myelogenous leukemia and acute lymphoblastic leukemia.
- Navitoclax: A drug that has been used in trials studying the treatment of lymphoma, leukemia, and solid tumors.
Potential Applications[edit | edit source]
Senolytics have potential applications in a variety of age-related diseases, including:
- Cardiovascular disease: Senescent cells contribute to the development and progression of cardiovascular disease. Senolytics could potentially be used to reduce the burden of these cells and slow the progression of the disease.
- Osteoarthritis: Senescent cells accumulate in the joints with age and contribute to the development of osteoarthritis. Senolytics could potentially be used to reduce the burden of these cells and slow the progression of the disease.
- Alzheimer's disease: Senescent cells contribute to the development and progression of Alzheimer's disease. Senolytics could potentially be used to reduce the burden of these cells and slow the progression of the disease.
Research[edit | edit source]
Research into senolytics is ongoing, with several clinical trials currently underway. These trials aim to determine the safety and efficacy of senolytics in humans.
See Also[edit | edit source]
References[edit | edit source]
| Senolytic Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
