Sertoli cells

Sertoli cells are a type of cell found in the testis, specifically in the seminiferous tubules. They are named after the Italian physiologist Enrico Sertoli, who discovered them. Sertoli cells play a crucial role in spermatogenesis, the process of sperm production.

Function

Sertoli cells are responsible for creating a suitable environment for the development of spermatozoa. They provide physical support, nourishment, and protection to the developing sperm cells. They also secrete various substances that regulate the process of spermatogenesis.

Structure

Sertoli cells are large, columnar cells that extend from the basement membrane to the lumen of the seminiferous tubules. They have a unique shape that allows them to envelop and interact with the developing sperm cells.

Clinical significance

Abnormalities in Sertoli cells can lead to various reproductive disorders. For example, Sertoli cell-only syndrome is a condition where only Sertoli cells, but no sperm cells, are present in the seminiferous tubules. This leads to male infertility.

See also

• Leydig cells
• Spermatogenesis
• Testis

References

Sertoli cells Resources
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