Sex-determining region Y protein

Sex-determining region Y protein (also known as SRY protein or testis-determining factor) is a DNA-binding protein encoded by the SRY gene that is responsible for the initiation of male sex determination in humans.

Function

The SRY protein is a transcription factor that is encoded on the Y chromosome. It is responsible for the initiation of male sex determination in humans. The SRY protein binds to other proteins and to specific areas of DNA and controls the activity of other genes, particularly those involved in the development of male sexual characteristics.

Structure

The SRY protein is composed of 204 amino acids and has a molecular weight of approximately 23 kDa. The protein contains a high mobility group (HMG) box domain, which is responsible for DNA binding and bending, and a bridge domain, which is involved in protein-protein interactions.

Role in Disease

Mutations in the SRY gene can lead to a range of disorders of sex development (DSDs), including Swyer syndrome, Androgen insensitivity syndrome, and Gonadal dysgenesis. These conditions are characterized by atypical development of sexual characteristics and reproductive anatomy.

See Also

• Sex determination
• Y chromosome
• Sex-determining region Y
• Androgen insensitivity syndrome
• Swyer syndrome
• Gonadal dysgenesis

References

Sex-determining region Y protein Resources
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