Sigma-1
Sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. In humans, the sigma-1 receptor is encoded by the SIGMAR1 gene.
Function[edit | edit source]
The sigma-1 receptor acts as a chaperone at the ER-mitochondrion interface. It has been found to bind various ligands, such as psychoactive drugs, including cocaine and methamphetamine. It also interacts with some other proteins, such as BiP and GRP78.
Clinical significance[edit | edit source]
Sigma-1 receptors are implicated in the drug addiction and the diseases like Alzheimer's disease, Parkinson's disease, and cancer. They might also have a role in the treatment of depression, as they are thought to be involved in the mechanism of action of some antidepressants.
Ligands[edit | edit source]
Many ligands bind to sigma-1 receptors to produce pharmacological effects. Some of them are used for therapeutic purposes, while others are used in scientific research.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- Sigma-1 receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
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