Small nucleolar RNA SNORD64
Small nucleolar RNA SNORD64 (SNORD64), also known as U64, is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modification is necessary for the maturation of pre-ribosomal RNA (rRNA) into mature rRNA, a key component of the ribosome. SNORD64 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (RUGAUGA) and the D box (CUGA). These molecules are involved in guiding the 2'-O-ribose methylation of rRNA molecules. SNORD64 is located within the introns of its host gene, which is a common characteristic of many snoRNAs.
Function[edit | edit source]
SNORD64 is involved in the biogenesis of the ribosome, the cellular structure responsible for protein synthesis. By guiding the 2'-O-methylation of specific residues on rRNA, SNORD64 plays a critical role in the structural and functional maturation of the ribosome. This modification process is essential for the accurate and efficient translation of mRNA into protein.
Biogenesis and Structure[edit | edit source]
Like other C/D box snoRNAs, SNORD64 is characterized by its conserved C and D boxes, which are crucial for its function in rRNA modification. The biogenesis of SNORD64 involves its transcription as part of a host gene, followed by processing to remove intronic sequences and form the mature snoRNA. The structure of SNORD64, like other snoRNAs, allows it to form complexes with specific proteins, forming small nucleolar ribonucleoproteins (snoRNPs). These complexes are essential for the snoRNA to perform its function in the nucleus.
Clinical Significance[edit | edit source]
While the specific clinical implications of SNORD64 have not been extensively characterized, dysregulation of snoRNAs, in general, has been associated with various diseases, including cancer. Abnormal expression levels of snoRNAs can affect ribosome biogenesis and function, potentially leading to altered protein synthesis and disease pathogenesis.
Related Pages[edit | edit source]
This RNA related article is a stub. You can help WikiMD by expanding it.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
