Spider lamb syndrome

Spider lamb syndrome (SLS) is a genetic disorder that affects the skeletal system of sheep. It is characterized by a number of deformities, including long, thin limbs and a twisted spine. The syndrome is caused by a mutation in the fibroblast growth factor receptor 2 (FGFR2) gene.

Causes

Spider lamb syndrome is caused by a mutation in the FGFR2 gene. This gene provides instructions for making a protein that is involved in the development and maintenance of bone and brain tissue. When the FGFR2 gene is mutated, it leads to abnormal development of the skeletal system.

Symptoms

The most common symptoms of spider lamb syndrome include:

• Long, thin limbs
• Twisted spine
• Deformed chest
• Difficulty walking or standing

Diagnosis

Diagnosis of spider lamb syndrome is typically made based on physical examination and genetic testing. The physical examination may reveal the characteristic skeletal abnormalities, while genetic testing can confirm the presence of the mutated FGFR2 gene.

Treatment

There is currently no cure for spider lamb syndrome. Treatment is supportive and aimed at managing symptoms. This may include physical therapy to improve mobility and surgical intervention to correct skeletal deformities.

Prevention

Prevention of spider lamb syndrome involves genetic testing and selective breeding. By identifying sheep that carry the mutated FGFR2 gene, breeders can avoid breeding these animals and thus prevent the syndrome from being passed on to future generations.

See also

• Genetic disorder
• Fibroblast growth factor receptor 2
• Sheep

Spider lamb syndrome Resources
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