Spilanthol

Spilanthol is an alkamide found in the Acmella oleracea plant, also known as the "toothache plant" or "paracress". It is a bioactive compound that has been studied for its various potential therapeutic applications.

Chemistry

Spilanthol is a fatty acid amide derivative, specifically an N-isobutylamide. It is a lipophilic compound, meaning it is soluble in fats and oils but not in water. Its chemical structure includes a 15-carbon chain with a amide group at one end.

Pharmacology

Spilanthol has been found to have several pharmacological effects. It is most well-known for its local anesthetic effects, which is why Acmella oleracea is often used in traditional medicine for toothache. It works by blocking sodium channels in nerve cells, preventing the transmission of pain signals.

In addition to its anesthetic effects, spilanthol has also been found to have antimicrobial, antifungal, antioxidant, and anti-inflammatory properties. It has been studied for potential use in treating a variety of conditions, from skin diseases to digestive disorders.

Potential Therapeutic Applications

Research into the potential therapeutic applications of spilanthol is ongoing. Some studies have suggested that it may be useful in treating periodontal disease, due to its antimicrobial and anti-inflammatory effects. Other research has looked at its potential use in skin care products, due to its antioxidant properties and its ability to stimulate the production of collagen.

Safety

While spilanthol is generally considered safe for topical use, it can cause a tingling or numbing sensation. Oral consumption of spilanthol, such as in herbal teas made from Acmella oleracea, is also generally considered safe, although it can cause a similar numbing sensation in the mouth and throat.

See Also

• Acmella oleracea
• Alkamide
• Anesthetic
• Antimicrobial
• Anti-inflammatory