Spindle

Spindle refers to a structure that forms during cell division to separate chromosomes between daughter cells. It is a key component of cell division and is crucial for the accurate segregation of genetic material.

Structure

The spindle is composed of microtubules, which are dynamic filamentous cytoskeletal proteins. The microtubules are organized in a bipolar manner, with the plus ends pointing towards the chromosomes and the minus ends anchored at the centrosomes. The centrosomes, also known as spindle poles, are the main microtubule organizing centers in the cell.

Function

The primary function of the spindle is to ensure that each daughter cell receives an equal complement of chromosomes during cell division. The spindle achieves this by attaching to the chromosomes via specialized structures called kinetochores and moving them to opposite poles of the cell. This process is tightly regulated to ensure that all chromosomes are properly attached and aligned before the cell divides.

Regulation

The formation and function of the spindle is regulated by a variety of proteins and signaling pathways. Key regulators include the Aurora kinase family, the kinesin motor proteins, and the cyclin-dependent kinase (CDK) family. These proteins regulate spindle assembly, chromosome attachment, and the timing of cell division.

Clinical significance

Defects in spindle function can lead to errors in chromosome segregation, which can result in aneuploidy, a condition characterized by an abnormal number of chromosomes. Aneuploidy is a common feature of many types of cancer and is thought to contribute to tumor progression and drug resistance.

See also

• Mitosis
• Meiosis
• Cell cycle
• Cytoskeleton

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