Trimipramine
(Redirected from Stangyl)
A tricyclic antidepressant
| Trimipramine | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Trimipramine is a tricyclic antidepressant (TCA) used in the treatment of depression. It is known for its sedative properties and is often prescribed for patients with insomnia associated with depression. Trimipramine is marketed under various brand names, including Surmontil.
Pharmacology[edit | edit source]
Trimipramine works by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine, thereby increasing their levels in the synaptic cleft and enhancing neurotransmission. Unlike other TCAs, trimipramine has a unique mechanism of action as it also acts as an antagonist at certain serotonin receptors, which may contribute to its antidepressant effects.
Medical uses[edit | edit source]
Trimipramine is primarily used to treat major depressive disorder. It is particularly effective in patients who experience anxiety and sleep disturbances as part of their depressive symptoms. Due to its sedative effects, it is often prescribed for patients with insomnia.
Side effects[edit | edit source]
Common side effects of trimipramine include dry mouth, constipation, blurred vision, and drowsiness. It may also cause orthostatic hypotension, which is a drop in blood pressure upon standing. As with other TCAs, there is a risk of cardiotoxicity in overdose.
Interactions[edit | edit source]
Trimipramine can interact with other medications, including monoamine oxidase inhibitors (MAOIs), which can lead to serious side effects. It may also interact with alcohol, enhancing its sedative effects.
History[edit | edit source]
Trimipramine was first introduced in the 1960s and has been used in clinical practice for several decades. It remains a valuable option for patients who do not respond to other antidepressants.
Related pages[edit | edit source]
References[edit | edit source]
Trimipramine 2D Structure
Trimipramine Ball-and-Stick Model
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
