Ciclopirox
(Redirected from Stieprox)
Ciclopirox
Ciclopirox[edit | edit source]
Ciclopirox is a synthetic, broad-spectrum antifungal agent renowned for its multifaceted pharmacological activities, which include not only antifungal properties but also antibacterial and anti-inflammatory effects. Predominantly used to treat fungal infections, Ciclopirox operates through a distinct mechanism of chelating essential trivalent cations.
Overview[edit | edit source]
As a versatile pharmaceutical, Ciclopirox is incorporated in various formulations, such as creams, lotions, and nail lacquers, and is frequently prescribed for dermal fungal infections as well as certain nail infections.
Mechanism of Action[edit | edit source]
Ciclopirox's antifungal action is exerted primarily through its ability to bind to and chelate trivalent cations, notably Fe^3+ and Al^3+. By doing so, it disrupts:
- Enzyme Activity: The chelation limits the availability of essential cofactors needed for critical enzymes. This, in turn, results in a loss of activity of these enzymes, which are pivotal for various cellular metabolic processes.
- Cell Wall Integrity: The binding interferes with enzymes necessary for maintaining cell wall structure, compromising the cellular protective barrier.
Furthermore, Ciclopirox's anti-inflammatory prowess arises from its inhibitory effects on enzymatic pathways:
- 5-Lipoxygenase Inhibition: This enzyme is pivotal in the synthesis of leukotrienes, which are involved in inflammatory responses.
- Cyclooxygenase (COX) Inhibition: COX enzymes play a key role in the production of prostaglandins, another group of compounds integral to inflammation.
Therapeutic Uses[edit | edit source]
Given its broad-spectrum activity, Ciclopirox is employed in treating:
- Dermal Fungal Infections: Such as athlete's foot, jock itch, and ringworm.
- Nail Infections: The nail lacquer form is particularly used for fungal infections of the nail.
- Yeast Infections: Such as those caused by Candida species.
Side Effects[edit | edit source]
While generally well-tolerated, some patients might experience:
- Skin irritation or burning at the application site
- Redness or itching
- Dry or discolored skin
Precautions[edit | edit source]
Patients are advised to inform their healthcare providers about any allergies or other medications they are on before starting treatment with Ciclopirox.
References[edit | edit source]
Resources[edit source]
Latest articles - Ciclopirox
Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Ciclopirox for any updates.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Kondreddy Naveen