Streptokinase

Streptokinase is a thrombolytic medication and enzyme produced by streptococci bacteria. It is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism. The use of streptokinase is contraindicated in cases of recent surgery, hemorrhagic stroke, or active bleeding.

Mechanism of Action[edit | edit source]

Streptokinase works by combining with plasminogen to form an active complex that can convert other plasminogen molecules into plasmin. Plasmin is an enzyme that breaks down fibrin, a protein that forms the framework of blood clots.

Side Effects[edit | edit source]

Common side effects of streptokinase include nausea, vomiting, low blood pressure, and bleeding. Serious side effects may include allergic reactions and major bleeding.

History[edit | edit source]

Streptokinase was discovered in 1933. It was the first thrombolytic medication to be approved for use in heart attacks.

References[edit | edit source]

External Links[edit | edit source]

Streptokinase on Drugs.com
Streptokinase on PubMed

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