Stromagen
Stromagen is a protein that in humans is encoded by the ADAMTS9 gene. It is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
Function[edit | edit source]
Stromagen is involved in the breakdown of the extracellular matrix, a critical process in the development of arthritis and cancer. It is also involved in angiogenesis, the process by which new blood vessels are formed.
Clinical significance[edit | edit source]
Mutations in the ADAMTS9 gene have been associated with genetic disorders such as Ehlers-Danlos syndrome, a group of disorders affecting the connective tissues that support the skin, bones, blood vessels, and other organs and tissues.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
