Structural Classification of Proteins database

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The Structural Classification of Proteins database (SCOP) is a comprehensive resource that classifies and organizes protein structures based on their evolutionary and structural relationships. SCOP provides valuable insights into the diversity and evolution of protein structures, aiding researchers in understanding the functions and relationships of proteins.

History

The SCOP database was first developed in 1994 by Alexey Murzin, Tim Hubbard, and Cyrus Chothia at the MRC Laboratory of Molecular Biology in Cambridge, UK. It was created to address the need for a systematic classification of protein structures to facilitate research in structural biology and bioinformatics.

Structure

SCOP categorizes protein structures into a hierarchical classification scheme that includes several levels of organization. The primary levels of classification in SCOP are:

• Class: Represents the broadest level of classification based on the overall fold of the protein.
• Fold: Refers to the arrangement of secondary structural elements within the protein structure.
• Superfamily: Groups proteins with similar structures and functions that are likely to have evolved from a common ancestor.
• Family: Defines a group of proteins that share significant sequence and structural similarities.

Usage

Researchers and scientists use the SCOP database to explore the relationships between different protein structures, identify evolutionary connections, and predict the functions of uncharacterized proteins. By leveraging the information in SCOP, researchers can gain valuable insights into the structural and functional properties of proteins.

Importance

The SCOP database plays a crucial role in structural biology and bioinformatics by providing a standardized classification system for protein structures. It serves as a valuable resource for studying protein evolution, structure-function relationships, and protein-ligand interactions.

See also

• Protein structure
• Protein classification
• Bioinformatics

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This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC​)