Sulodexide
Sulodexide is a highly purified mixture of glycosaminoglycans (GAGs) composed of low molecular weight heparin (80%) and dermatan sulfate (20%). It is an antithrombotic agent with properties including anticoagulant, profibrinolytic, anti-inflammatory, and endothelial protective effects.
Etymology[edit | edit source]
The term "Sulodexide" is derived from the Latin words 'sulcus' meaning groove and 'dexter' meaning right. The name is indicative of the compound's ability to correctly groove or align the body's physiological processes.
Pharmacology[edit | edit source]
Sulodexide is used in the treatment of venous diseases such as chronic venous insufficiency and venous ulcers. It is also used in the management of vascular diseases of the eye, diabetic nephropathy, and arterial diseases such as atherosclerosis and peripheral artery disease.
The mechanism of action of sulodexide involves its interaction with various components of the coagulation cascade, leading to a decrease in thrombin generation and an increase in fibrinolysis. It also has anti-inflammatory properties and can protect the endothelium from damage.
Side Effects[edit | edit source]
Common side effects of sulodexide include nausea, vomiting, diarrhea, and abdominal pain. Rare side effects can include allergic reactions such as rash, itching, and swelling.
Related Terms[edit | edit source]
- Glycosaminoglycans
- Heparin
- Dermatan sulfate
- Antithrombotic
- Anticoagulant
- Venous diseases
- Chronic venous insufficiency
- Venous ulcers
- Vascular diseases
- Diabetic nephropathy
- Arterial diseases
- Atherosclerosis
- Peripheral artery disease
- Coagulation cascade
- Thrombin
- Fibrinolysis
- Endothelium
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Allergic reactions
- Rash
- Itching
- Swelling
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Contributors: Prab R. Tumpati, MD
