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Steroidogenesis inhibitors are a class of drugs that inhibit the production of steroids, which are essential for a variety of physiological functions. They are used in the treatment of a variety of conditions, including Cushing's syndrome, prostate cancer, and breast cancer.

Mechanism of action

Steroidogenesis inhibitors work by blocking the enzymes that are involved in the production of steroids. These enzymes include 17α-hydroxylase, CYP17A1, and aromatase. By inhibiting these enzymes, these drugs can reduce the levels of steroids in the body.

Uses

Steroidogenesis inhibitors are used in the treatment of a variety of conditions. These include:

• Cushing's syndrome: This is a condition caused by an overproduction of the steroid hormone cortisol. Steroidogenesis inhibitors can be used to reduce the levels of cortisol in the body.

• Prostate cancer: Some forms of prostate cancer are stimulated by the steroid hormone testosterone. Steroidogenesis inhibitors can be used to reduce the levels of testosterone in the body, thereby slowing the growth of the cancer.

• Breast cancer: Some forms of breast cancer are stimulated by the steroid hormone estrogen. Steroidogenesis inhibitors can be used to reduce the levels of estrogen in the body, thereby slowing the growth of the cancer.

Side effects

Like all drugs, steroidogenesis inhibitors can have side effects. These can include fatigue, nausea, and hot flashes. In some cases, these drugs can also cause a decrease in bone density, which can lead to osteoporosis.

See also

• CYP17A1 inhibitor
• Aromatase inhibitor
• Steroid

References

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