Decamethonium
(Redirected from Syncurine)
Decamethonium is a synthetic alkane bisammonium compound used as a neuromuscular-blocking drug or muscle relaxant in anesthesia. It is a depolarizing neuromuscular-blocking drug, causing persistent depolarization of the motor end plate. It is no longer in clinical use in developed countries due to the risk of histamine release and cardiovascular side effects.
Etymology[edit | edit source]
The name "Decamethonium" is derived from its structure, as it is a decane with two ammonium groups.
Pharmacology[edit | edit source]
Decamethonium primarily acts by blocking the action of acetylcholine, a neurotransmitter, at the neuromuscular junction. This results in muscle paralysis, which is useful in surgical procedures where muscle relaxation is required. However, its use has been largely discontinued due to the risk of severe side effects.
Side Effects[edit | edit source]
The side effects of Decamethonium include hypotension, bradycardia, and arrhythmias. These are primarily due to the release of histamine from mast cells. It can also cause an increase in intraocular pressure, which can be problematic in patients with glaucoma.
History[edit | edit source]
Decamethonium was first synthesized in the 1940s and was used in anesthesia for several decades. However, its use has been largely discontinued due to the development of safer and more effective neuromuscular-blocking drugs.
See Also[edit | edit source]
Decamethonium Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD