Syrosingopine
Overview[edit | edit source]
Syrosingopine is a pharmaceutical compound known for its role as an antihypertensive agent. It is a derivative of reserpine, a well-known alkaloid used in the treatment of high blood pressure. Syrosingopine functions by depleting catecholamines and serotonin from peripheral sympathetic nerve endings, leading to a decrease in blood pressure.
Mechanism of Action[edit | edit source]
Syrosingopine works primarily by inhibiting the vesicular monoamine transporter 2 (VMAT2), which is responsible for the uptake of neurotransmitters such as norepinephrine, dopamine, and serotonin into synaptic vesicles. By blocking this transporter, syrosingopine reduces the storage of these neurotransmitters in vesicles, leading to their depletion in the synaptic cleft and a subsequent decrease in sympathetic nervous system activity.
Clinical Uses[edit | edit source]
Syrosingopine has been used in the management of hypertension, particularly in cases where other treatments have proven ineffective. Its use, however, has declined with the development of newer antihypertensive agents that have more favorable side effect profiles.
Side Effects[edit | edit source]
The side effects of syrosingopine are similar to those of reserpine and include depression, nasal congestion, gastrointestinal disturbances, and bradycardia. Due to its ability to deplete neurotransmitters, it can also lead to symptoms of depression and sedation.
Pharmacokinetics[edit | edit source]
Syrosingopine is administered orally and is absorbed through the gastrointestinal tract. It is metabolized in the liver and excreted primarily through the kidneys. The drug has a relatively long half-life, which allows for once-daily dosing.
Related Compounds[edit | edit source]
Syrosingopine is chemically related to other rauwolfia alkaloids, such as reserpine. These compounds share a similar mechanism of action and are used in the treatment of hypertension and certain psychiatric disorders.
Research and Development[edit | edit source]
Recent studies have explored the potential of syrosingopine in combination with other drugs for the treatment of cancer. Its ability to inhibit VMAT2 has been investigated for its potential to enhance the efficacy of certain chemotherapeutic agents.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
