T-regulatory cell

T-regulatory cells (also known as Tregs or Treg cells) are a type of T cell that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease. Tregs are immunosuppressive and generally suppress or downregulate induction and proliferation of effector T cells.

Function

Tregs control the immune response in several ways. They can inhibit the proliferation of T cells and B cells, suppress the production of cytokines, and promote the induction of immune tolerance. Tregs are also involved in preventing autoimmune disease by suppressing the immune response to self-antigens.

Types

There are several types of Tregs, including natural Tregs (nTregs), induced Tregs (iTregs), and peripheral Tregs (pTregs). nTregs are generated in the thymus, while iTregs and pTregs are generated in the periphery.

Clinical significance

Tregs play a crucial role in maintaining immune homeostasis and preventing autoimmunity. However, they can also suppress beneficial immune responses, such as those against cancer and infection. Therefore, the manipulation of Tregs has potential therapeutic implications in a variety of diseases, including cancer, autoimmune disease, and transplant rejection.

See also

• Immune system
• T cell
• Autoimmune disease
• Cancer
• Transplant rejection

External links

• T Regulatory Cells and Their Counterparts: Masters of Immune Regulation

T-regulatory cell Resources
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