TAB1

TAB1 or TGF-beta activated kinase 1/MAP3K7 binding protein 1 is a protein that in humans is encoded by the TAB1 gene. TAB1 is a critical component of the TGF-beta signaling pathway. It binds to TAK1 and aids in its activation upon the stimulation of TGF-beta.

Function

TAB1 is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of NF-kappaB and JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB2; this complex is required for the activation of MAP3K7 following engagement of the Toll-like receptors. MAP3K7 activated by the binding of TAB1 to TRAF6, which is required for K63-linked polyubiquitination of TRAF6, and the subsequent activation of IKK and NF-kappaB.

Clinical significance

Mutations in TAB1 have been associated with congenital heart defects.

Interactions

TAB1 has been shown to interact with:

• MAP3K7
• TRAF6
• CSNK2A1
• CSNK2A2
• CSNK2B

External links

• TAB1 at the National Center for Biotechnology Information

See also

• TGF-beta
• TAK1
• TRAF6
• NF-kappaB
• JNK
• Toll-like receptors
• Polyubiquitination
• Congenital heart defects
• Protein-protein interaction
• MAP3K7
• CSNK2A1
• CSNK2A2
• CSNK2B
• National Center for Biotechnology Information