TAX1BP3

Protein TAX1BP3 PDB 2KG2

TAX1BP3

TAX1BP3 is a gene that encodes the protein Tax1-binding protein 3. This protein plays a crucial role in various cellular processes, including the regulation of immune responses and cell growth. Mutations in the TAX1BP3 gene have been associated with certain diseases and disorders.

Function

The primary function of TAX1BP3 is to interact with the Tax1 protein, which is produced by the human T-cell leukemia virus type 1 (HTLV-1). By binding to Tax1, TAX1BP3 helps regulate the activity of this viral protein and its effects on host cells. Additionally, TAX1BP3 is involved in the autophagy process, which is essential for maintaining cellular homeostasis and eliminating damaged organelles.

Clinical Significance

Mutations in the TAX1BP3 gene have been linked to certain autoimmune diseases and cancers. Dysregulation of TAX1BP3 expression can disrupt normal immune responses and contribute to the development of inflammatory conditions. Furthermore, alterations in TAX1BP3 function may impact cell proliferation and survival, potentially leading to tumorigenesis.

Interactions

TAX1BP3 interacts with various proteins involved in immune signaling pathways and autophagy. These interactions are critical for the proper functioning of the immune system and the maintenance of cellular health. By modulating the activity of these proteins, TAX1BP3 helps coordinate a balanced immune response and cellular maintenance.