TEAD3

TEAD3 (TEA Domain Family Member 3) is a protein that in humans is encoded by the TEAD3 gene. This protein is part of the TEAD family of transcription factors, which play a crucial role in regulating gene expression linked to cell growth and proliferation. The TEAD family members are characterized by a highly conserved TEA/ATTS domain that is essential for their binding to DNA and for the transcriptional activation of downstream target genes.

Function

TEAD3, like other members of the TEAD family, functions as a transcription factor by binding to the TEA/ATTS domain in the promoters of target genes. This interaction is critical for the regulation of gene expression involved in various cellular processes, including development, differentiation, and proliferation. TEAD3 has been shown to interact with co-activators such as YAP1 (Yes-associated protein 1) and TAZ (WWTR1), which are part of the Hippo signaling pathway. This pathway plays a significant role in controlling organ size by regulating cell proliferation and apoptosis.

The interaction between TEAD3 and its co-activators is essential for the transcriptional activation of genes that promote cell growth and inhibit apoptosis. Dysregulation of the Hippo pathway and TEAD3's role within it can contribute to the development of cancer and other diseases by promoting unchecked cell proliferation and survival.

Clinical Significance

Alterations in the expression or function of TEAD3 have been implicated in various pathological conditions, including cancer. Overexpression of TEAD3, often in conjunction with dysregulation of the Hippo pathway, has been observed in certain types of cancer, suggesting a potential role in tumorigenesis. As a result, TEAD3 and the Hippo pathway are of interest as potential targets for therapeutic intervention in cancer and other diseases characterized by abnormal cell growth and proliferation.

Gene

The TEAD3 gene is located on human chromosome 6. It encodes the TEAD3 protein, which is expressed in various tissues throughout the body, indicating its importance in multiple cellular functions and processes.

See Also

• Transcription factor
• Hippo signaling pathway
• YAP1
• TAZ
• Cancer
• Apoptosis
• Cell proliferation