TOX4
TOX4 (TOX High Mobility Group Box Family Member 4) is a protein that in humans is encoded by the TOX4 gene. This protein is part of the TOX family, which is characterized by containing a high mobility group (HMG) box domain. The TOX proteins play critical roles in the regulation of DNA binding and thus are involved in the control of gene expression, particularly in the immune system and during cell differentiation and development.
Function[edit | edit source]
The TOX4 protein is involved in various cellular processes, including the regulation of gene expression, cell cycle progression, and the maintenance of chromatin structure. It is known to interact with the PARP1 (Poly [ADP-ribose] polymerase 1) protein, playing a role in the repair of DNA damage and maintaining genomic stability. Through its interaction with PARP1, TOX4 participates in the regulation of transcription by modulating the structure of chromatin, thereby influencing the accessibility of genes to the transcriptional machinery.
Clinical Significance[edit | edit source]
While the full clinical significance of TOX4 is still under investigation, alterations in the expression or function of TOX4 have been implicated in various cancers. Its role in DNA repair and gene expression regulation suggests that TOX4 could be involved in the development and progression of cancer through mechanisms such as the promotion of genomic instability or the dysregulation of genes critical for cell growth and survival. Further research is necessary to fully understand the potential of TOX4 as a biomarker for cancer or as a target for therapeutic intervention.
Gene and Expression[edit | edit source]
The TOX4 gene is located on chromosome 14q32.33 in humans. It is expressed in various tissues, with significant levels observed in the testis, brain, and heart. The expression of TOX4, like other members of the TOX family, is tightly regulated, suggesting its importance in the maintenance of normal cellular functions and its potential involvement in disease when dysregulated.
See Also[edit | edit source]
 | This genetics article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
