TSHB
TSHB or Thyroid-stimulating hormone beta is a protein that in humans is encoded by the TSHB gene. The protein encoded by this gene is a beta subunit of thyroid-stimulating hormone (TSH). TSH, along with its alpha subunit, is produced by the pituitary gland and stimulates the thyroid gland to produce thyroxine (T4) and triiodothyronine (T3), both of which are important for metabolism and growth.
Function[edit | edit source]
The TSHB gene provides instructions for producing the beta subunit of the thyroid-stimulating hormone. This hormone plays a crucial role in controlling thyroid hormone production. The TSHB gene is located on the short (p) arm of chromosome 1 at position 31.2.
Clinical significance[edit | edit source]
Mutations in the TSHB gene can lead to congenital hypothyroidism due to TSH deficiency. This condition is characterized by low levels of thyroid hormones, leading to slow growth and delayed development.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
