Telokin

Telokin is a protein that in humans is encoded by the MYLK gene. This protein is a member of the myosin light chain kinase family and plays a crucial role in the regulation of muscle contraction. The MYLK gene produces four different products through alternative splicing, one of which is Telokin.

Function

Telokin is a smooth muscle-specific protein that is exclusively expressed in the gastrointestinal tract. It is a kinase that phosphorylates the regulatory light chain of myosin, thereby activating myosin ATPase and promoting muscle contraction. Telokin is unique in that it is not associated with the cytoskeleton and is freely diffusible within the cell.

Clinical significance

Mutations in the MYLK gene that encodes Telokin have been associated with aortic aneurysm, familial thoracic 9, and asthma. Further research is needed to fully understand the role of Telokin in these conditions.

See also

• Myosin light-chain kinase
• Smooth muscle tissue
• Aortic aneurysm
• Asthma

External links

• UniProt: MYLK

Telokin Resources
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