Template:Relative affinities of nandrolone and related steroids

From WikiMD's Wellness Encyclopedia

Relative affinities (%) of nandrolone and related steroids
Compound PR 
|| AR

|| ER

|| GR

|| MR

|| SHBG

|| CBG
Nandrolone 
|| 20 || 154–155 || <0.1 || 0.5 || 1.6 || 1–16 || 0.1
Testosterone 
|| 1.0–1.2 || 100 || <0.1 || 0.17 || 0.9 || 19–82 || 3–8
Estradiol 
|| 2.6 || 7.9 || 100 || 0.6 || 0.13 || 8.7–12 || <0.1
Notes: Values are percentages (%). Reference ligands (100%) were progesterone for the PR

, testosterone for the AR , estradiol for the ER , dexamethasone for the GR , aldosterone for the MR , dihydrotestosterone for SHBG , and cortisol for CBG . Sources: [1][2][3][4][5][6][7][8]

  1. ↑ , Steroid flexibility and receptor specificity, J. Steroid Biochem., Vol. 13(Issue: 1), pp. 45–59, DOI: 10.1016/0022-4731(80)90112-0, PMID: 7382482,
  2. ↑ , Towards the mapping of the progesterone and androgen receptors, J. Steroid Biochem., Vol. 27(Issue: 1–3), pp. 255–69, DOI: 10.1016/0022-4731(87)90317-7, PMID: 3695484,
  3. ↑ , Steroid hormone receptors and pharmacology, J. Steroid Biochem., Vol. 12 pp. 143–57, DOI: 10.1016/0022-4731(80)90264-2, PMID: 7421203,
  4. ↑ , Unique steroid congeners for receptor studies, Cancer Res., Vol. 38(Issue: 11 Pt 2), pp. 4186–98, PMID: 359134, Full text,
  5. ↑ , Affiliations among steroid receptors as revealed by multivariate analysis of steroid binding data, J. Steroid Biochem. Mol. Biol., Vol. 48(Issue: 1), pp. 31–46, DOI: 10.1016/0960-0760(94)90248-8, PMID: 8136304,
  6. ↑ , Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin, Endocrinology, Vol. 114(Issue: 6), pp. 2100–6, DOI: 10.1210/endo-114-6-2100, PMID: 6539197,
  7. ↑ , Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP), Steroids, Vol. 38(Issue: 3), pp. 243–62, DOI: 10.1016/0039-128X(81)90061-1, PMID: 7197818,
  8. ↑ , Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma, J. Clin. Endocrinol. Metab., Vol. 53(Issue: 1), pp. 69–75, DOI: 10.1210/jcem-53-1-69, PMID: 7195405,
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