Glucocorticoid receptor
Glucocorticoid receptor (GR) is a type of protein that is encoded by the NR3C1 gene in humans. It is a member of the nuclear receptor family of intracellular receptors and functions as a receptor for glucocorticoids such as cortisol (hydrocortisone).
Function[edit | edit source]
The glucocorticoid receptor is activated by binding of glucocorticoids. Once activated, it functions as a transcription factor, regulating the expression of specific genes. This regulation can either involve upregulation or downregulation of gene expression.
Structure[edit | edit source]
The glucocorticoid receptor is a protein that is composed of several domains. These include a DNA-binding domain (DBD), a ligand-binding domain (LBD), and two transactivation domains (TADs).
Clinical significance[edit | edit source]
Alterations in the function of the glucocorticoid receptor have been implicated in a variety of diseases, including Cushing's syndrome, Addison's disease, and rheumatoid arthritis. In addition, glucocorticoid receptor antagonists are used in the treatment of certain types of cancer.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
