Aldosterone

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Aldosterone[edit | edit source]

Aldosterone molecular structure

Aldosterone is a mineralocorticoid hormone produced by the adrenal cortex, in the adrenal gland. It plays a pivotal role in regulating sodium and potassium balance, and thus, has significant implications on blood pressure and fluid balance in the body.

Function[edit | edit source]

Aldosterone acts on the distal tubules and collecting ducts of the nephron (functional unit of the kidney) to:

  • Increase Sodium Reabsorption: This leads to water reabsorption, thereby increasing the blood volume and blood pressure.
  • Increase Potassium Excretion: To maintain electrolyte balance.

The secretion of Aldosterone is primarily regulated by the Renin-Angiotensin-Aldosterone System (RAAS).

Clinical Significance[edit | edit source]

  • Hyperaldosteronism: Excess production of Aldosterone can lead to hypertension and hypokalemia.
  • Addison's disease: A deficiency in Aldosterone production can result in low blood pressure and hyperkalemia.
  • Aldosterone antagonists: Medications such as spironolactone and eplerenone block the effects of Aldosterone and are used to treat conditions like heart failure and hypertension.

See Also[edit | edit source]

References[edit | edit source]

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