Tenascin X
Tenascin-X is a large extracellular matrix glycoprotein that plays a crucial role in the structural integrity of connective tissues. It is encoded by the TNXB gene located on chromosome 6 in humans.
Function[edit | edit source]
Tenascin-X is involved in the organization and maintenance of the extracellular matrix, which provides structural support to tissues and influences cell behavior. It is particularly important in the skin, muscles, and blood vessels.
Clinical significance[edit | edit source]
Mutations in the TNXB gene can lead to a condition known as Ehlers-Danlos syndrome type tenascin-X deficient, which is characterized by hyperelastic skin, joint hypermobility, and tissue fragility. This condition highlights the importance of tenascin-X in maintaining tissue integrity.
Interactions[edit | edit source]
Tenascin-X interacts with other extracellular matrix proteins and cell surface receptors, influencing cell adhesion, migration, and proliferation. These interactions are critical for tissue repair and development.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
