Bethanidine

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Bethanidine is a sympatholytic agent that was formerly used in the treatment of hypertension. It functions by blocking the release of norepinephrine from nerve endings and thus decreasing peripheral vascular resistance.

Mechanism of Action[edit | edit source]

Bethanidine works by blocking the release of norepinephrine, a neurotransmitter that is released from nerve endings. This neurotransmitter is responsible for the constriction of blood vessels, which leads to increased blood pressure. By blocking its release, Bethanidine helps to relax and widen blood vessels, thereby reducing blood pressure.

Uses[edit | edit source]

Bethanidine was primarily used in the treatment of hypertension. However, due to its side effects and the development of safer drugs, it is no longer commonly used.

Side Effects[edit | edit source]

The side effects of Bethanidine include dry mouth, dizziness, headache, fatigue, and orthostatic hypotension. In rare cases, it can cause hepatotoxicity.

Contraindications[edit | edit source]

Bethanidine is contraindicated in patients with heart failure, severe coronary artery disease, and pheochromocytoma. It should also be avoided in patients with a history of hepatic or renal impairment.

Interactions[edit | edit source]

Bethanidine can interact with other medications, including monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and beta-blockers. These interactions can lead to increased blood pressure and other adverse effects.

See Also[edit | edit source]

Bethanidine Resources
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